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NS Diazepam rectal gel is a gel formulation of diazepam intended for rectal administration in the management of selected, refractory, patients with epilepsy, on stable regimens of AEDs, who require intermittent use of diazepam to control bouts of increased seizure activity. Evidence to support the use of diazepam rectal gel was adduced in two controlled trials (see CLINICAL PHARMACOLOGY and CLINICAL STUDIES) that enrolled patients with partial onset or generalized convulsive seizures who were identified jointly by their caregivers and physicians as suffering intermittent and periodic episodes of markedly increased seizure activity, sometimes heralded by non-convulsive symptoms, that for the individual patient were characteristic and were deemed by the prescriber to be of a kind for which a benzodiazepine would ordinarily be administered acutely. Although these clusters or bouts of seizures differed among patients, for any individual patient the clusters of seizure activity were not onl adult dosage


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Y stereotypic but were judged by those conducting and participating in these studies to be distinguishable from other seizures suffered by that patient. The conclusion that a patient experienced such unique episodes of seizure activity was based on historical information. DOSAGE AND ADMINISTRATION This section is intended primarily for the prescriber, however, the prescriber should also be aware of the dosing information and directions for use provided in the patient package insert. A decision to prescribe diazepam rectal gel involves more than the diagnosis and the selection of the correct dose for the patient. First, the prescriber must be convinced from historical reports and or personal observations that the patient exhibits the characteristic identifiable seizure cluster that can be distinguished from the patient's usual seizure activity by the caregiver who will be responsible for administering diazepam rectal gel. Second, because diazepam rectal gel is only intended for adjuncti

adult dosage of valium for convenience as “Pediatric” adult dosage of valium, “Universal” and “Adult”. The 2.5 and 5 mg dosages are available with a 4.4 cm Pediatric tip adult dosage of valium, the 10 mg dosage is available with a 4.4 cm Universal tip and the 15 and 20 mg dosages are available with a 6.0 cm Adult tip. It is important to note that if a 15 mg dose is to be administered to a pediatric patient utilizing the plastic applicator with a pediatric tip adult dosage of valium, prescriptions must be written for 2 different twin packs adult dosage of valium, one for the 5 mg dosage and one for the 10 mg dosage (see HOW SUPPLIED). In elderly and debilitated patients adult dosage of valium, it is recommended that the dosage be adjusted downward to reduce the likelihood of ataxia or overseda adult dosage of valium.

adult dosage of valium Tion. The prescribed dose of diazepam rectal gel should be adjusted by the physician periodically to reflect changes in the patient's age or weight. It is recommended that dosage be reviewed at six month intervals. A 2.5 mg dose is available for use as a supplemental dose. This dose may be prescribed at the discretion of the physician for patients who require more precise dose titration than is achieved using one of the four standard doses provided. The 2.5 mg dose may also be used as a partial replacement dose for patients who may expel a portion of the first dose. Additional Dose: The prescriber may wish to prescribe a second dose of diazepam rectal gel. A second dose adult dosage of valium, when required adult dosage of valium, may be given 4-12 hours after the first dose. Treatment Frequency: It is recommended that diazepam rectal gel be used to treat no more than five episodes per month and no more than one episode every five days. HOW SUPPLIED Diastat (diazepam rectal gel) rectal delivery system is a non-sterile diazepam gel provided in a prefilled adult dosage of valium, unit-dose adult dosage of valium, rectal delivery system. The rectal delivery system includes a plastic applicator with a flexible adult dosage of valium, molded tip available in two lengths adult dosage of valium, designated for convenience as “Pediatric” adult dosage of valium, “Universal” or “Adult”. Diastat is available in the following five presentations: Each Twin Pack contains two Diastat .

adult dosage of valium Second dose adult dosage of valium, when required adult dosage of valium, may be given 4-12 hours after the first dose. Treatment Frequency: It is recommended that diazepam rectal gel be used to treat no more than five episodes per month and no more than one episode every five days. HOW SUPPLIED Diastat (diazepam rectal gel) rectal delivery system is a non-sterile diazepam gel provided in a prefilled adult dosage of valium, unit-dose adult dosage of valium, rectal delivery system. The rectal delivery system includes a plastic applicator with a flexible adult dosage of valium, molded tip available in two lengths adult dosage of valium, designated for convenience as “Pediatric” adult dosage of valium, “Universal” or “Adult”. Diastat is available in the following five presentations: Each Twin Pack contains two Diastat r.

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