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Tion by a factor of 2) Severe renal deficiencies (e.g. patients on dialysis) Severe sleep apnea Severe depression, particularly when accompanied by suicidal tendencies Acute intoxication with alcohol, narcotics, or other psychoactive substances Myasthenia gravis Hypersensitivity or allergy to any drug in the benzodiazepine class edit Special caution needed Pediatric patients Less than 18 years of age - Treatment usually not indicated, except treatment of epilepsy, and pre- postoperative treatment. The smallest possible effective dose should be used for this group of patients. 30 Under 6 months of age - Safety and effectiveness have not been established; diazepam should not be given to individuals in this age group. 7 30 Elderly and very ill patients - Possibility that apnea and or cardiac arrest may occur. Concomitant use of other central nervous system depressants increases this risk. The smallest possible effective dose should be used for this group of patients.. 7 30 33 I.V. or I.M. diazepam


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injections in hypotensive individuals or those in shock should be administered carefully and vital signs should be monitored. 33 edit Patients at a high risk for abuse and dependence Diazepam can lead to physiological tolerance, and psychological and or physical dependence citation needed . At a particularly high risk for diazepam misuse, abuse, and dependence are: Patients with a history of alcohol or drug abuse or dependence 7 34 Emotionally unstable patients citation needed Patients with severe personality disorders, such as Borderline Personality Disorder 35 Patients with chronic pain or other physical disorders citation needed Patients from the aforementioned groups should be monitored very closely during therapy for signs of abuse and development of dependence. Discontinue therapy if any of these signs are noted. Long-term therapy in these patients is not recommended. 7 34 The American Society of Addiction Medicine has policy indicating that patients with addictive disease shoul

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diazepam Gal status Internationally diazepam, diazepam is a Schedule IV drug under the Convention on Psychotropic Substances. 40 edit Physical properties Diazepam occurs as solid white or yellow crystals and has a melting point of 131.5 to 134.5°C. It is odorless diazepam, and has a slightly bitter taste. The British Pharmacopoeia lists diazepam as being very slightly soluble in water diazepam, soluble in alcohol and freely soluble in chloroform. The United States Pharmacopoeia lists diazepam as soluble 1 in 16 of ethyl alcohol diazepam, 1 in 2 of chloroform diazepam, 1 in 39 of ether diazepam, and practically insoluble in water. The pH of diazepam is neutral (i.e. 7). Diazepam has a shelf-life of 5 years for oral tablets and 3 years for IV IM solution. 13 Diazepam should be stored at room temperature (15°-30°C). The solution for parenteral injection should be protected from light and kept from freezing. The oral forms should be stored in air-tight containers and protected from light. 15 Diazepam can absorb into plastic diazepam, and therefore diazepam solution is not stored in plastic bottles or syringes. It can absorb into plastic bags and tubing used for intervenous infusions. Absorption appears to be dependent on several factors such as temperature diazepam, concentration diazepam, flow rates and tube length. Diazepam should not be administered if a precipitate has formed and will not dissolve.

diazepam Ts and 3 years for IV IM solution. 13 Diazepam should be stored at room temperature (15°-30°C). The solution for parenteral injection should be protected from light and kept from freezing. The oral forms should be stored in air-tight containers and protected from light. 15 Diazepam can absorb into plastic diazepam, and therefore diazepam solution is not stored in plastic bottles or syringes. It can absorb into plastic bags and tubing used for intervenous infusions. Absorption appears to be dependent on several factors such as temperature diazepam, concentration diazepam, flow rates and tube length. Diazepam should not be administered if a precipitate has formed and will not dissolve..

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diazepam Xetine (Prozac); isoniazide (INH, Laniazid, Nydrazid); ketoconazole (Nizoral); levodopa (Larodopa, Sinemet); medications for depression, seizures, pain, Parkinson's disease, asthma, colds, or allergies; metoprolol (Lopressor, Toprol XL); muscle relaxants; oral contraceptives; probenecid (Benemid); propoxyphene (Darvon); propranolol (Inderal); ranitidine (Zantac); rifampin (Rifadin); sedatives; sleeping pills; theophylline (Theo-Dur); tranquilizers; valproic acid (Depakene); and vitamins. These medications may add to the drowsiness caused by diazepam. if you use antacids, take diazepam first, then wait 1 hour before taking the antacid. tell your doctor if you have or have ever had glaucoma; seizures; or lung, heart, or liver disease. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking diazepam, call your doctor immediately. if you are having surgery, including dental surgery, tell the doctor or dentist that you are ta

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