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actual dose for any given day. 13 15 Diazepam is metabolised in the liver via the cytochrome P450 enzyme system. It has a biphasic half-life of 1-2 and 2-5 days, and has several pharmacologically active metabolites. The main active metabolite of diazepam is desmethyldiazepam (also known as nordazepam or nordiazepam). Diazepam's other active metabolites include temazepam and oxazepam. These metabolites are conjugated with glucuronide, and are excreted primarily in the urine. Because of these active metabolites, the serum values of diazepam alone are not useful in predicting the effects of the drug. 1 15 Diazepam has a half-life (t1 2α) of 20-50 hours, and desmethyldiazepam has a half-life of 30-200 hours. 15 Most of the drug is metabolised; very little diazepam is excreted unchanged. 13 In humans, the protein binding of diazepam is around 98.5%. 1 edit Indications Diazepam is mainly used to treat anxiety, insomnia, and symptoms of acute alcohol or opiate withdrawal. It is also used as
what is the half life of valium Bolism of other compounds. There is no evidence that would suggest diazepam alters its own metabolism with chronic administration. 13 Agents which have an effect on hepatic cytochrome P450 pathways or conjugation can alter the rate of diazepam metabolism. These interactions would be expected to be most significant with long-term diazepam therapy what is the half life of valium, and their clinical significance is variable. 13 Diazepam increases the central depressive effects of alcohol what is the half life of valium, other hypnotics sedatives (e.g. barbiturates) what is the half life of valium, narcotics what is the half life of valium, and other muscle relaxants. The euphoriant effects of opioids may be increased what is the half life of valium, leading to increased risk of psychological dependence. 29 30 Cimetidi what is the half life of valium.
what is the half life of valium Ne what is the half life of valium, omeprazole what is the half life of valium, ketoconazole what is the half life of valium, itraconazole what is the half life of valium, disulfiram what is the half life of valium, fluvoxamine what is the half life of valium, isoniazid what is the half life of valium, erythromycin what is the half life of valium, probenecid what is the half life of valium, propranolol what is the half life of valium, imipramine what is the half life of valium, ciprofloxacin what is the half life of valium, fluoxetine and valproic acid prolong the action of diazepam by inhibiting its elimination. 13 15 Oral contraceptives ("the pill") significantly decrease the elimination of desmethyldiazepam what is the half life of valium, a major metabolite of diazepam. 30 Rifampin what is the half life of valium, phenytoin what is the half life of valium, carbamazepine and phenobarbital increase the metabolism of diazepam what is the half life of valium, thus decreasing drug levels and effects. 13 Nefazodone can cause increased blood levels of benzodiazepines. 30 Cisapride may enhance the absorption what is the half life of valium, and therefore the sedative activity what is the half life of valium, of diazepam. 31 Small doses of theophylline may inhibit the action of diazepam. 32 Diazepam may block the action of levodopa (used in the treatment of Parkinson's Disease). 29 Diazepam may alter digoxin serum concentrations. 13 Other drugs that may have interactions with diazepam include: Antipsychotics (e.g. chlorpromazine) what is the half life of valium, MAO inhibitors what is the half life of valium, ranitidine. 30 Smoking tobacco can enhance the elimination of diazepam and decrease its action. 29 Foods that acidify the urine can lead to faster absorption and elimination of diazepam what is the half life of valium, reducing drug levels and activity. 29 Foods that alkalinize the urine can lead to slower absorption and elimination of diazepam what is the half life of valium, increasing drug levels an.
what is the half life of valium Ll doses of theophylline may inhibit the action of diazepam. 32 Diazepam may block the action of levodopa (used in the treatment of Parkinson's Disease). 29 Diazepam may alter digoxin serum concentrations. 13 Other drugs that may have interactions with diazepam include: Antipsychotics (e.g. chlorpromazine) what is the half life of valium, MAO inhibitors what is the half life of valium, ranitidine. 30 Smoking tobacco can enhance the elimination of diazepam and decrease its action. 29 Foods that acidify the urine can lead to faster absorption and elimination of diazepam what is the half life of valium, reducing drug levels and activity. 29 Foods that alkalinize the urine can lead to slower absorption and elimination of diazepam what is the half life of valium, increasing drug levels and.
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