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chondroitin products are marketed as "dietary supplements." Glucosamine is available in many forms, including glucosamine sulfate, glucosamine hydrochloride (HCl), and N-acetylglucosamine (NAG), and may also contain a potassium chloride or sodium chloride salt. However, there appears to be no conclusive evidence that one form is better than another 7 . Chondroitin is typically sold as chondroitin sulfate. In December 1999 and January 2000, ConsumerLab.com tested 25 brands of glucosamine, chondroitin and combination products and found that (a) all 10 glucosamine-only products, passed the test but 2 chondroitin-only and 6 out of 13 combination products did not (because their chondroitin levels were too low). In January 2001, one of the combination products was removed because its manganese level was judged to be too high. In 2001, Consumer Reports evaluated 19 products and reported: Most . . . were reasonably well standardized, delivering at least 90 percent of the amount of g glucosamine hydrochloride


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Lucosamine or chondroitin promised on the label, thereby meeting a new standard for the supplements proposed by the U.S. Pharmacopeia, which sets standards for drugs and proposes them for supplements. But four products & 8212;Now Double Strength Glucosamine & Chondroitin, ArthxDS Glucosamine Chondroitin, Solgar Extra Strength Glucosamine Chondroitin Complex, and Now Chondroitin Sulfate& 8212;failed to meet that standard. Two products& 8212;Solgar Extra Strength Glucosamine Chondroitin Complex and Twinlab CSA (Chondroitin Sulfate)& 8212;recommended too few pills per day to supply the dose used in the successful clinical trials. Several others listed the recommended number of pills as a range that permits consumers to take a dose that may be inadequate 8 . In 2001, Vital Nutrients recalled two products (Vital Nutrients Joint Ease and Verified Quality Joint Comfort) that had been found to contain aristolochic acid, a substance that can cause kidney toxicity and cancer 9 . Safety Consi

glucosamine hydrochloride potassium chloride or sodium chloride salt. However glucosamine hydrochloride, there appears to be no conclusive evidence that one form is better than another 7 . Chondroitin is typically sold as chondroitin sulfate. In December 1999 and January 2000 glucosamine hydrochloride, ConsumerLab.com tested 25 brands of glucosamine glucosamine hydrochloride, chondroitin and combination products and found that (a) all 10 glucosamine-only products glucosamine hydrochloride, passed the test but 2 chondroitin-only and 6 out of 13 combination products did not (because their chondroitin levels were too low). In January 2001 glucosamine hydrochloride, one of the combination products was removed because its manganese level was judged to be too high. In 2001 glucosamine hydrochloride, Consumer Reports evaluated 19 products and glucosamine hydrochloride.

glucosamine hydrochloride reported: Most . . . were reasonably well standardized glucosamine hydrochloride, delivering at least 90 percent of the amount of glucosamine or chondroitin promised on the label glucosamine hydrochloride, thereby meeting a new standard for the supplements proposed by the U.S. Pharmacopeia glucosamine hydrochloride, which sets standards for drugs and proposes them for supplements. But four products & 8212;Now Double Strength Glucosamine & Chondroitin glucosamine hydrochloride, ArthxDS Glucosamine Chondroitin glucosamine hydrochloride, Solgar Extra Strength Glucosamine Chondroitin Complex glucosamine hydrochloride, and Now Chondroitin Sulfate& 8212;failed to meet that standard. Two products& 8212;Solgar Extra Strength Glucosamine Chondroitin Complex and Twinlab CSA (Chondroitin Sulfate)& 8212;recommended too few pills per day to supply the dose used in the successful clinical trials. Several others listed the recommended number of pills as a range that permits consumers to take a dose that may be inadequate 8 . In 2001 glucosamine hydrochloride, Vital Nutrients recalled two products (Vital Nutrients Joint Ease and Verified Quality Joint Comfort) that had been found to contain aristolochic acid glucosamine hydrochloride, a substance that can cause kidney toxicity and cancer 9 . Safety Considerations No study so far has found any serious side effects from either glucosamine or chondroitin. The most common side effects are increased intestinal gas and softened stools. However glucosamine hydrochloride, animal research has raised the possibi.

glucosamine hydrochloride few pills per day to supply the dose used in the successful clinical trials. Several others listed the recommended number of pills as a range that permits consumers to take a dose that may be inadequate 8 . In 2001 glucosamine hydrochloride, Vital Nutrients recalled two products (Vital Nutrients Joint Ease and Verified Quality Joint Comfort) that had been found to contain aristolochic acid glucosamine hydrochloride, a substance that can cause kidney toxicity and cancer 9 . Safety Considerations No study so far has found any serious side effects from either glucosamine or chondroitin. The most common side effects are increased intestinal gas and softened stools. However glucosamine hydrochloride, animal research has raised the possibil.

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glucosamine hydrochloride Osamine sulfate is stabilized with sodium chloride (table salt) and can contain as much as 30% sodium. This is a consideration for individuals who want to reduce their dietary intake of sodium. Glucosamine hydrochloride offers the promise of the same efficacy as glucosamine sulfate, since glucosamine is not absorbed intact with its carrier. The body doesn’t care how it gets glucosamine as long as it is bioavailable. Nonetheless, we embarked on clinical research to prove the efficacy of the hydrochloride form. We first conducted pilot testing, which indicated benefit for those with osteoarthritis. We then went forward with a full-scale, double-blind, placebo-controlled intervention trial with glucosamine hydrochloride, the results, of which, are published in the Journal of Rheumatology listed in the references on the next page. Results showed a strong, beneficial effect for between 60 and 70% of the subjects, compared to their baseline symptoms. Other clinical studies “Pharmacokinetics

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