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Comitantly at therapeutic doses. Tramadol does not appear to induce its own metabolism in humans, since observed maximal plasma concentrations after multiple oral doses are higher than expected based on single-dose data. Tramadol is a mild inducer of selected drug metabolism pathways measured in animals. Use With Carbamazepine Patients taking carbamazepine may have a significantly reduced analgesic effect of tramadol. Because carbamazepine increases tramadol metabolism and because of the seizure risk associated with tramadol, concomitant administration of ULTRACET and carba-mazepine is not recommended. Use With Quinidine Tramadol is metabolized to M1 by CYP2D6. Quinidine is a selective inhibitor of that isoenzyme; so that concomitant administration of quinidine and tramadol results in increased concentrations of tramadol and reduced concentrations of M1. The clinical consequences of these findings are unknown. In vitro drug interaction studies in human liver microsomes indicate that tr side effects


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Amadol has no effect on quinidine metabolism. Use With Inhibitors of CYP2D6 In vitro drug interaction studies in human liver microsomes indicate that concomitant administration with inhibitors of CYP2D6 such as fluoxetine, paroxetine, and amitripty-line could result in some inhibition of the metabolism of tramadol. Use With Cimetidine Concomitant administration of ULTRACET and cime-tidine has not been studied. Concomitant administration of tramadol and cimetidine does not result in clinically significant changes in tramadol pharmacokinetics. Therefore, no alteration of the ULTRACET dosage regimen is recommended. Use With MAO Inhibitors Interactions with MAO Inhibitors, due to interference with detoxification mechanisms, have been reported for some centrally acting drugs (see WARNINGS, Use With MAO Inhibitors). Use With Digoxin Post-marketing surveillance of tramadol has revealed rare reports of digoxin toxicity. Use With Warfarin Like Compounds Post-marketing surveillance of both trama

side effects of tramadol hydrochloride E rate of treatment-emergent adverse events over five days of ULTRACET use in clinical trials (subjects took an average of at least 6 tablets per day). Table 2: Incidence of Treatment-Emergent Adverse Events (³ 2.0%) ULTRACET (N=142) Body System Preferred Term % Gastrointestinal System Constipation 6 Diarrhea 3 Nausea 3 Dry Mouth 2 Psychiatric Disorders Somnolence 6 Anorexia 3 Insomnia 2 Central & Peripheral Nervous System Dizziness 3 Skin and Appendages Sweating Increased 4 Pruritus 2 Reproductive Disorders side effects of tramadol hydrochloride, Male* Prostatic Disorder 2 *Number of males = 62 Incidence at least 1% side effects of tramadol hydrochloride, causal relationship at least possible or greater: the following lists adver side effects of tramadol hydrochloride.

side effects of tramadol hydrochloride Se reactions that occurred with an incidence of at least 1% in single-dose or repeated-dose clinical trials of ULTRACET. Body as a Whole –Asthenia side effects of tramadol hydrochloride, fatigue side effects of tramadol hydrochloride, hot flushes Central and Peripheral Nervous System –Dizziness side effects of tramadol hydrochloride, headache side effects of tramadol hydrochloride, tremor Gastrointestinal System – Abdominal pain side effects of tramadol hydrochloride, constipation side effects of tramadol hydrochloride, diarrhea side effects of tramadol hydrochloride, dyspepsia side effects of tramadol hydrochloride, flatulence side effects of tramadol hydrochloride, dry mouth side effects of tramadol hydrochloride, nausea side effects of tramadol hydrochloride, vomiting Psychiatric Disorders –Anorexia side effects of tramadol hydrochloride, anxiety side effects of tramadol hydrochloride, confusion side effects of tramadol hydrochloride, euphoria side effects of tramadol hydrochloride, insomnia side effects of tramadol hydrochloride, nervousness side effects of tramadol hydrochloride, somnolence Skin and Appendages – Pruritus side effects of tramadol hydrochloride, rash side effects of tramadol hydrochloride, increased sweating. Selected Adverse events occurring at less than 1%: the following lists clinically relevant adverse reactions that occurred with an incidence of less than 1% in ULTRACET clinical trials. Body as a Whole – Chest pain side effects of tramadol hydrochloride, rigors side effects of tramadol hydrochloride, syncope side effects of tramadol hydrochloride, withdrawal syndrome Cardiovascular Disorders – Hypertension side effects of tramadol hydrochloride, aggravated hypertension side effects of tramadol hydrochloride, hypotension Central and Peripheral Nervous System – Ataxia side effects of tramadol hydrochloride, convulsions side effects of tramadol hydrochloride, hypertonia side effects of tramadol hydrochloride, migraine side effects of tramadol hydrochloride, aggravated migraine side effects of tramadol hydrochloride, involuntary muscle contractions side effects of tramadol hydrochloride, paraesthesia side effects of tramadol hydrochloride, stupor side effects of tramadol hydrochloride, vertigo Gastrointestinal System– Dysphagia side effects of tramadol hydrochloride, melena side effects of tramadol hydrochloride, tongue edema Hearing and Vestibular Disorders – Tinnitus Heart Rate and Rhythm Disorders – Arrhythmia side effects of tramadol hydrochloride, palpitation side effects of tramadol hydrochloride, tachycardia Liver and Biliary System – Hepatic function abnormal Metabolic and Nutritional Disorders – Weight decrease Psychiatric Disorders – Amnesia side effects of tramadol hydrochloride, depersonalizati.

side effects of tramadol hydrochloride ULTRACET clinical trials. Body as a Whole – Chest pain side effects of tramadol hydrochloride, rigors side effects of tramadol hydrochloride, syncope side effects of tramadol hydrochloride, withdrawal syndrome Cardiovascular Disorders – Hypertension side effects of tramadol hydrochloride, aggravated hypertension side effects of tramadol hydrochloride, hypotension Central and Peripheral Nervous System – Ataxia side effects of tramadol hydrochloride, convulsions side effects of tramadol hydrochloride, hypertonia side effects of tramadol hydrochloride, migraine side effects of tramadol hydrochloride, aggravated migraine side effects of tramadol hydrochloride, involuntary muscle contractions side effects of tramadol hydrochloride, paraesthesia side effects of tramadol hydrochloride, stupor side effects of tramadol hydrochloride, vertigo Gastrointestinal System– Dysphagia side effects of tramadol hydrochloride, melena side effects of tramadol hydrochloride, tongue edema Hearing and Vestibular Disorders – Tinnitus Heart Rate and Rhythm Disorders – Arrhythmia side effects of tramadol hydrochloride, palpitation side effects of tramadol hydrochloride, tachycardia Liver and Biliary System – Hepatic function abnormal Metabolic and Nutritional Disorders – Weight decrease Psychiatric Disorders – Amnesia side effects of tramadol hydrochloride, depersonalizatio.

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side effects of tramadol hydrochloride F serious trouble. Possible food and drug interactions when taking Ultram Ultram may increase the drowsiness caused by alcohol. Do not drink alcohol while taking Ultram. Avoid Ultram, too, if you are taking the seizure medication Tegretol. If Ultram is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Ultram with the following: Cyclobenzaprine (Flexeril) Drugs known as MAO inhibitors, including the antidepressants Nardil and Parnate Serotonin-boosting antidepressants such as Paxil, Prozac, and Zoloft "Tricyclic" antidepressants such as Elavil, Norpramin, and Tofranil Major tranquilizers such as Thorazine and Stelazine Narcotic pain relievers (Demerol, morphine, Darvon, Percocet) Promethazine (Mepergan, Phenergan) Quinidine (Quinidex) Sleeping pills (Halcion, Dalmane, Restoril) Tranquilizers (Valium, Xanax) Special information if you are pregnant or breastfeeding There ha