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Ost ingestion. Treatment of Overdose A single or multiple overdose with ULTRACET may be a potentially lethal polydrug overdose, and consultation with a regional poison control center is recommended. In treating an overdose of ULTRACET, primary attention should be given to maintaining adequate ventilation along with general supportive treatment. While nalox-one will reverse some, but not all, symptoms caused by overdosage with tramadol, the risk of seizures is also increased with naloxone administration. In animals, convulsions following the administration of toxic doses of tramadol could be suppressed with barbiturates or benzodiazepines but were increased with naloxone. Naloxone administration did not change the lethality of an overdose in mice. Based on experience with tramadol, hemodialysis is not expected to be helpful in an overdose because it removes less than 7% of the administered dose in a 4-hour dialysis period. Standard recommendations should be followed for the treatment of
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